Scientists Figured Out The Origin Of Ovarian Cancer

In past we may have been looking it in the wrong place


A new research on Ovarian Cancer has suggested that Ovarian cancer hold in the fallopian tube(between the ovaries and the uterus), instead of ovaries themselves.

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This study is going to change the way we are using in detecting and treating with this deadly diseases and can save many lives.

One of the researcher said that it’s hard to catch Ovarian cancer in it’s early stage and it well-developed with time but this discovery can help us in catching this diseases in it’s early stage, it means we can save many lives.

International team of researchers emphasises that these findings are still preliminary because this study is based on only nine women tissue sample.

Researchers told that after holding this study on a large scale, if we find the same result than we will have a vastly improved method of attack for this type of cancer.

Senior researcher Victor Velculescu said that “Ovarian cancer treatments have not changed much in many decades and this may be because we have been studying the wrong tissue of origin for these cancers”.

Ovarian Cancer (leading cause of death)

Ovarian Cancer is the leading cause of death from gynecologic cancers. The 10-year survival is <30% and has not improved significantly over the last 30 years. Despite of many effort, screening and therapeutic strategies have generally not led to improved overall survival.

Result Of Study

For this study, researchers collected tissue samples from five women Who had been diagnosed with sporadic HGSOC (High-Grade serous ovarian carcinoma), and tissue sample from four women who had removed their ovaries due to being at a high genetic risk of developing the diseases.

Tissue sample includes normal cells. ovarian cancer cells, small cancer from the fallopian tubes and cancerous cells that had spread elsewhere.

Using infrared laser and staining technology, researcher were able to extract the small number of cancer cells found in the fallopian tubes and use genome sequencing to catalogue the protein-coding genes present in cell’s DNA.

When result came that was surprising for the researchers team because end result was a series of DNA sequences relating only to the cancer cells rather than normal cells and this allowed the team to examine them for biological coding mistakes.


How cancer cells, shown in purple, ‘seed’ from the fallopian tube. (Carolyn Hruban)

Researchers found that cancer cells from all nine patients had lost identical regions of chromosome 17, which should be at where the p53 gene is located.

Researchers told that the earliest cancer cells would have fewer mutations and through this we were able to link the diseases with the early-stage STIC lesions in the fallopian tubes of the five women who had been diagnosed with ovarian cancer.

Velculescu says “The window of time that exists between the development of a STIC lesion and metastatic diseases highlights the importance of new screening approaches such as liquid biopsy method for early detection of Ovarian Cancer.”

Further statistical analysis showed the tumours developed quickly once they reached the ovaries, something backed up by clinical diagnosis.

Source – This research has been published in Nature Communications and we use data from Nature Communication and ScienceAlert

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